![]() Together, these structures provide insight into how the hinge-bending movement of GGBP facilitates ligand binding, transport, and signaling.ĭepartment of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA. Furthermore, the high-quality data collected for the atomic resolution glucose-bound structure allow for the refinement of specific hydrogen atom positions, the assignment of alternate side chain conformations, the first description of CO(2) trapped after radiation-induced decarboxylation, and insight into the role of the exo-anomeric effect in sugar binding. A comparison with the closely related periplasmic receptors, ribose- and allose-binding proteins, shows that the GGBP hinge residue positions that undergo the largest conformational changes are different. The structure of the enzyme from Aspergillus niger, previously refined at 2.3 A resolution, has been refined at 1.9 A resolution to an R value of 19. Download royalty-free stock photos, vectors, HD footage and more on Adobe Stock. ![]() These structures vary in the angle between the two structural domains the observed difference of 31 degrees arises from torsion angle changes in a three-segment hinge. Glucose oxidase is a flavin-dependent enzyme which catalyses the oxidation of beta-D-glucose by molecular oxygen to delta-gluconolactone and hydrogen peroxide. Search from thousands of royalty-free Glucose Structure stock images and video for your next project. We report a 0.92 angstroms resolution structure of GGBP from Escherichia coli in the glucose-bound state and the first structure of an open, unbound form of GGBP (at 1.55 angstroms resolution). GGBP, like other periplasmic binding proteins, can exist in open (ligand-free) and closed (ligand-bound) states. Diversity, Equity, Inclusion, and Accessĭ-Glucose/D-Galactose-binding protein (GGBP) mediates chemotaxis toward and active transport of glucose and galactose in a number of bacterial species.Citation, Usage, Privacy Policies, Logo.Biologically Interesting Molecule Reference Dictionary (BIRD).
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